A Mini Review on Genes Associated with in vitro and in vivo Carbon Nanotubes Toxicity

Abstract

Carbon nanotubes (CNTs) are the most extensively used nanomaterials due to their unique properties and diverse applications. The potential toxicity caused due to the exposure of CNTs in vitro and in vivo is being widely studied. This mini review provides information about the genes responsible for inflammatory, fibrotic and apoptotic responses during single and multi-walled CNT toxicity. Based on published literature, the upregulated pro-inflammatory genes are EGR1, ATF3, FGF21, EGF1 and CD9 and downregulated ones are TOB2, CD47, FOXO3 and RORA. The genes associated with fibrosis are MMP-2, MMP-8, IL23A, EDNRA, MMP-9, TIMP-1, CDK4, UBD and with apoptosis are p16, bax, hrk, bak1, p53, p57 and FGFR2. This mini review is an attempt at compiling the genes responsible for CNT toxicity. Future work aims at creating a database of genes associated with CNT toxicity.

Keywords: Carbon nanotubes (CNTs), genes, in vitro, in vivo, toxicity

Cite this Article

V. Vijayalakshmi, Bindu Sadanandan. A Mini Review on Genes Associated with in vitro and in vivo Carbon Nanotubes Toxicity. Research & Reviews: A Journal of Life Sciences. 2019; 9(Issue 1 Special): 73s–78s.