A review on the effects of Indian medicinal spices on age related molecular and cellular pathways in light of geriatric muscle loss
Abstract
Biological aging is an enigmatic and progressive process, which can be affected by various mechanisms - genetic alteration, deregulated nutrient sensing, proteostasis, cellular degeneration and stem cell dysfunctioning. Indian spices are an underexplored repository of phytoactives with a medicinal potential. Especially spices like cumin (Cuminum-cyminum) and fennel seeds (Foeniculum vulgare) are central to the Indian diet as well as a part of numerous traditional recipes and formulations with medicinal implications. Large part of the preclinical and clinical investigations on medicinal benefits of spices are centered around their phytochemical compounds such as thymoquinone, thymol, diosgenin, 4-hydroxyisoleucine, furostanolic etc in terms of associated mechanistic pathways modulated and their cellular and physiological benefits. In this review, we perform a systematic study of evidence-based phytochemicals from the enlisted spices that can exert a positive impact on aging related molecular and cellular functions. In the end we also summarize their implications on preserving age-related muscle mass in terms of their anti-inflammatory, anti-diabetic, anti-oxidant, muscle regeneration capacity and anti-fatigue action.
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References
Ruan L, Zhang X, Li R. Recent insights into the cellular and molecular determinants of aging. J Cell Sci. 2018 Feb 2;131(3):jcs210831. doi: 10.1242/jcs.210831. PMID: 29420249; PMCID: PMC5826050.
Guo J, Huang X, Dou L, Yan M, Shen T, Tang W, Li J. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct Target Ther. 2022 Dec 16;7(1):391. doi: 10.1038/s41392-022-01251-0. PMID: 36522308; PMCID: PMC9755275.
Wilkinson DJ, Piasecki M, Atherton PJ. The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. Ageing Res Rev. 2018 Nov;47:123-132. doi: 10.1016/j.arr.2018.07.005. Epub 2018 Jul 23. PMID: 30048806; PMCID: PMC6202460.
Wani SA, Ahmad R, Gulzar R, Rashid I, Khuroo AA. Alien flora causes biotic homogenization in the biodiversity hotspot regions of India. Sci Total Environ. 2023 Aug 1;884:163856. doi: 10.1016/j.scitotenv.2023.163856. Epub 2023 May 2. PMID: 37142012.
Ganapathy A, Nieves JW. Nutrition and Sarcopenia-What Do We Know? Nutrients. 2020 Jun 11;12(6):1755. doi: 10.3390/nu12061755. PMID: 32545408; PMCID: PMC7353446.
Anton SD, Hida A, Mankowski R, Layne A, Solberg LM, Mainous AG, Buford T. Nutrition and Exercise in Sarcopenia. Curr Protein Pept Sci. 2018;19(7):649-667. doi: 10.2174/1389203717666161227144349. PMID: 28029078.
Bagherniya M, Mahdavi A, Shokri-Mashhadi N, Banach M, Von Haehling S, Johnston TP, Sahebkar A. The beneficial therapeutic effects of plant-derived natural products for the treatment of sarcopenia. J Cachexia Sarcopenia Muscle. 2022 Dec;13(6):2772-2790. doi: 10.1002/jcsm.13057. Epub 2022 Aug 12. PMID: 35961944; PMCID: PMC9745475.
Domaniku A, Bilgic SN, Kir S. Muscle wasting: emerging pathways and potential drug targets. Trends Pharmacol Sci. 2023 Oct;44(10):705-718. doi: 10.1016/j.tips.2023.07.006. Epub 2023 Aug 17. PMID: 37596181.
Cohen S, Nathan JA, Goldberg AL. Muscle wasting in disease: molecular mechanisms and promising therapies. Nat Rev Drug Discov. 2015 Jan;14(1):58-74. Doi: 10.1038/nrd4467. PMID: 25549588.
Graham ZA, Lavin KM, O'Bryan SM, Thalacker-Mercer AE, Buford TW, Ford KM, Broderick TJ, Bamman MM. Mechanisms of exercise as a preventative measure to muscle wasting. Am J Physiol Cell Physiol. 2021 Jul 1;321(1):C40-C57. doi:
1152/ajpcell.00056.2021. Epub 2021 May 5. PMID: 33950699; PMCID: PMC8424676.
Yin L, Li N, Jia W, Wang N, Liang M, Yang X, Du G. Skeletal muscle atrophy: From mechanisms to treatments. Pharmacol Res. 2021 Oct;172:105807. doi: 10.1016/j.phrs.2021.105807. Epub 2021 Aug 10. PMID: 34389456.
Picca A, Calvani R, Cesari M, Landi F, Bernabei R, Coelho-Júnior HJ, Marzetti E. Biomarkers of Physical Frailty and Sarcopenia: Coming up to the Place? Int J Mol Sci. 2020 Aug 6;21(16):5635. doi: 10.3390/ijms21165635. PMID: 32781619; PMCID: PMC7460617.
Huot JR, Baumfalk D, Resendiz A, Bonetto A, Smuder AJ, Penna F. Targeting Mitochondria and Oxidative Stress in Cancer- and Chemotherapy-Induced Muscle Wasting. Antioxid Redox Signal. 2023 Feb;38(4-6):352-370. doi: 10.1089/ars.2022.0149. Epub 2022 Dec 29. PMID: 36310444; PMCID: PMC10081727.
Dao T, Green AE, Kim YA, Bae SJ, Ha KT, Gariani K, Lee MR, Menzies KJ, Ryu D. Sarcopenia and Muscle Aging: A Brief Overview. Endocrinol Metab (Seoul). 2020 Dec;35(4):716-732. doi: 10.3803/EnM.2020.405. Epub 2020 Dec 23. PMID: 33397034; PMCID: PMC7803599.
Tezze C, Romanello V, Desbats MA, Fadini GP, Albiero M, Favaro G, Ciciliot S, Soriano ME, Morbidoni V, Cerqua C, Loefler S, Kern H, Franceschi C, Salvioli S, Conte M, Blaauw B, Zampieri S, Salviati L, Scorrano L, Sandri M. Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence. Cell Metab. 2017 Jun 6;25(6):1374-1389.e6. doi: 10.1016/j.cmet.2017.04.021. Epub 2017 May 25. PMID: 28552492; PMCID: PMC5462533.
Marzetti E, Calvani R, Cesari M, Buford TW, Lorenzi M, Behnke BJ, Leeuwenburgh C. Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials. Int J Biochem Cell Biol. 2013 Oct;45(10):2288-301. doi: 10.1016/j.biocel.2013.06.024. Epub 2013 Jul 8. PMID: 23845738; PMCID: PMC3759621.
Krishnapura Srinivasan, Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects, Food Quality and Safety, Volume 2, Issue 1, March 2018, Pages 1–16, https://doi.org/10.1093/fqsafe/fyx031
Hadi A, Mohammadi H, Hadi Z, Roshanravan N, Kafeshani M. Cumin (Cuminum cyminum L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2018 Nov;32(11):2146-2154. doi: 10.1002/ptr.6162. Epub 2018 Aug 8. PMID: 30088304.
Mnif S, Aifa S. Cumin (Cuminum cyminum L.) from traditional uses to potential biomedical applications. Chem Biodivers. 2015 May;12(5):733-42. doi: 10.1002/cbdv.201400305. PMID: 26010662.
Korinek M, Handoussa H, Tsai YH, Chen YY, Chen MH, Chiou ZW, Fang Y, Chang FR, Yen CH, Hsieh CF, Chen BH, El-Shazly M, Hwang TL. Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs. Front Pharmacol. 2021 Oct 11;12:674095. doi: 10.3389/fphar.2021.674095. PMID: 34707494; PMCID: PMC8545060.
Singh N, Yadav SS, Kumar S, Narashiman B. A review on traditional uses, phytochemistry, pharmacology, and clinical research of dietary spice Cuminum cyminum L. Phytother Res. 2021 Sep;35(9):5007-5030. doi: 10.1002/ptr.7133. Epub 2021 Apr 23. PMID: 33893678.
Kalaivani P, Saranya RB, Ramakrishnan G, Ranju V, Sathiya S, Gayathri V, Thiyagarajan LK, Venkhatesh JR, Babu CS, Thanikachalam S. Cuminum cyminum, a dietary spice, attenuates hypertension via endothelial nitric oxide synthase and NO pathway in renovascular hypertensive rats. Clin Exp Hypertens. 2013;35(7):534-42. doi: 10.3109/10641963.2013.764887. Epub 2013 Feb 12. PMID: 23402543.
https://www.mdpi.com/2076-3921/13/1/6
https://www.sciencedirect.com/science/article/pii/S0753332221006909
https://www.researchgate.net/publication/313742829_The_pharmacological_activities_of_Cuminum_cyminum_-A_review
Choi EM, Hwang JK. Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia. 2004 Sep;75(6):557-65. doi: 10.1016/j.fitote.2004.05.005. PMID: 15351109.
https://www.sciencedirect.com/science/article/abs/pii/S0023643802002268
Cherbal A, Bouabdallah M, Benhalla M, Hireche S, Desdous R. Phytochemical Screening, Phenolic Content, and Anti-Inflammatory Effect of Foeniculum vulgare Seed Extract. Prev Nutr Food Sci. 2023 Jun 30;28(2):141-148. doi: 10.3746/pnf.2023.28.2.141. PMID: 37416792; PMCID: PMC10321444.
(Kataoka H, Horiyama S, Yamaki M, Oku H, Ishiguro K, Katagi T, Takayama M, Semma M, Ito Y. Anti-inflammatory and anti-allergic activities of hydroxylamine and related compounds. Biol Pharm Bull. 2002 Nov;25(11):1436-41. doi: 10.1248/bpb.25.1436. PMID: 12419955.)
Samadi-Noshahr Z, Hadjzadeh MA, Moradi-Marjaneh R, Khajavi-Rad A. The hepatoprotective effects of fennel seeds extract and trans-Anethole in streptozotocin-induced liver injury in rats. Food Sci Nutr. 2020 Dec 30;9(2):1121-1131. doi: 10.1002/fsn3.2090. PMID: 33598196; PMCID: PMC7866591.
https://www.mdpi.com/2227-9717/10/5/982
DOI: https://doi.org/10.37591/rrjofst.v12i3.3876
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