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Phytochemical Investigation, Safety and Efficacy Evaluation of Calpurnia aurea (ssps): Commonly Used Traditional Medicinal Plant in Ethiopia: A Compressive Review

Ayana Beressa Debela


In Ethiopia, Calpurnia aurea (digita), a traditional medicinal plant is used for the treatment of syphilis, malaria, rabies, diabetes, hypertension, diarrhoea, leishmaniasis, trachoma, elephantiasis, fungal diseases and different other ailment of human and animals. It is important to find a scientific evidence for the traditional use and standardization of the medicinal plant to ensure safety, efficacy and quality through preliminary phytochemical screening, analysis, safety and efficacy studies. Based on this review, scientific studies conducted on Calpurnia aurea—a traditional medicinal plant found in Ethiopia—revealed that the leaves, bark, seed and root of the plant have potential medicinal values for various diseases and validate its traditional uses. Further studies of detailed phytochemical screening, further isolations and characterizations of each active ingredients is required to identify the exact chemical compound (s) responsible for the activities observed from the present studies for development of potential new drugs and applications in pharmaceutical industry. It is also important to conduct clinical trial in human subject to incorporate the medicinal plant to modern healthcare system and for standardization.


Traditional medicine, Calpurnia aurea, phytochemical analysis, safety and efficacy

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World Health Organization. General guidelines for methodologies on research and evaluation of traditional medicine. Geneva: WHO; 2000 (WHO/EDM/TRM/2000.1).

World Health Organization Regional Office for Africa. Promoting the role of traditional medicine in health systems. A strategy for the African region. Harare: World Health Organization Regional Office for Africa; 2000 (AFR/RC50/9).

Korir E, Joyce JK, Neil RC, Nivan M, Neil AK. Isoflavones from Calpurnia aurea Subsp. aurea and their Anticancer Activity. Afr J Tradit Complement Altern Med. 2014; 11: 33–37p.

Brehan T, Hedberg O, Tadesse M, Frils I, Hedberg I, Edwards S. Flora of Ethiopia. Addis Ababa: National Herbarium, Science Faculty; 1989.

Notten A. Calpurnia aurea (Aiton) Benth.subsp. aurea. SANBI Institutional Repository [Internet]; 2005. Available from: [accessed on 2020 sep 12; 5:30 AM].

Gemechu A, Mirutse G, Adane W, Gobena A. In vitro Antimycobacterial activity of selected medicinal plants against Mycobacterium tuberculosis and Mycobacterium bovis Strains. BMC Complem Alternat Med. 2013; 13: 291p.

7.Tadeg H. Phytopharmaceutical Studies of Some Selected Medicinal Plants Locally Used in the Treatment of Skin Disorders. Ethiopia: AAU Institutional Repository; 2004.

Blum, Bekele A. Storing grains as a survival strategy of small farmers in Ethiopia. J Int Agric Ext. 2002; 9: 77–83p.

Krishnaiah D, Sarbatly R, Bono A. Phytochemical antioxidants for health and medicine: A move towards nature. Biotechnol Mol Biol Rev. 2007; 1: 97–104p.

Nandagopal S, Kumari RBD. Phytochemical and antibacterial studies of Chicory (Cichorium intybus L.)-A multipurpose medicinal plant. Advan Biol Res. 2007; 1(1–2): 17–21p.

Kamboj VP. Herbal medicine. Curr Sci. 2000; 78: 35–39p.

World Health Organization. General guidelines for methodologies on and research and evaluation of traditional medicine. Geneva: WHO; 2000.

Dula DE, Zelalem A. Antioxidant Activity Assessment of Calpurnia aurea Root Extract. Nat Prod Chem Res. 2018, 6: 2p.

Mulata HN, Gnanasekara N, Malaku U, Seifu D. Phytochemical Screening and Assessment of In Vitro Antioxidant Activities of Calpurnia aurea Seeds and Leaves. Int J Pharm Pharma Sci. 2014; 2(2): 1–12p.

Eyasu A, Gebreselassie HB. Phytochemical Screening of the Leaves Calpurnia aurea (Ait.) Benth Extract. IJCCLM. 2019; 5(4): 18–24p.

Gebre W. Phytochemical Analysis and Antibacterial Activities of Organic Solvent extracts of Calpurnia aurea seed, root bark and root. MSc Thesis report; 2019 Jul.

Korir E, Kiplimo JJ, Crouch NR, Moodley N, Koorbanally NA. Isoflavones from Calpurnia aurea Subsp. aurea and Their Anticancer Activity. Afr J Tradit Complement Altern Med. 2014; 11(5): 33–37p.

Mengistu W, Daniel S, Gnanasekaran N. Antilipidemic Properties of Calpurnia aurea Leaf Extract on High Fat Diet Induced Hyperlipidemia. Pharmacogn Res. 2019; 11(4): 389–395p.

Umer S, Tekewe A, Kebede N. Antidiarrhoeal and antimicrobial activity of Calpurnia aurea leaf extract. BMC Complementary and Alternative Medicine. 2013; 13: 21p.

Melese A, Dobo B, Mikru A. Antibacterial activities of Calpurnia aurea and Ocimum lamiifolium extracts against selected gram positive and gram-negative bacteria. Ethiop J Sci Technol. 2019; 12(3): 203–220p.

Eyasu M, Shibeshi W, Giday M. In vivo antimalarial activity of hydromethanolic leaf extract of Calpurnia aurea (Fabaceae) in Mice infected with chloroquine sensitive Plasmodium berghei. Int J Pharm Pharmacol. 2013; 2(9): 131–142p.

Belayneh YM, Birru EM. Antidiabetic Activities of Hydromethanolic Leaf Extract of Calpurnia aurea (Ait.) Benth. Subspecies aurea (Fabaceae) in Mice. Evid Based Complement Alternat Med. 2018; Article ID 3509073: 9p.

Getiye Y. Evaluation of In Vivo Antihypertensive and Ex Vivo Vasodepressor Activities of the Seed Extract of Calpurnia aurea (Ait.) Benth.subsp. aurea (Fabaceae). MSc Thesis report; 2014 Mar.

Kenubih A, Belay M, Awol N, Birhan M. Extraction and Phytochemical Screening of Culpurina aurea Leaves and Their Effect against Malopaagus ovinus. Asian J Med Pharm Res. 2019; 9(1): 1–10p.

Hiruy B, Getu E. Efficacy of solvent extracts of Calpurnia aurea (Ait.) Benth and Milletia ferruginea (Hochest) Baker leaves against maize weevils, Sitophilus zeamais (Motsch.) of stored maize in Ethiopia. J Stored Prod Postharvest Res.2018; 9(3): 27–35p.


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