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Pharmaceutical Standardization and Preliminary assay of Kokilaksha (Asteracantha longifolia nees.) Ghana
Abstract
Introduction: Kokilaksha (Asteracantha longifolia Nees.) is an annual herb belonging to the acanthaceae family. In classics, Kokilaksha Kwatha (Decoction) is stated in the treatment of Nidranasha (Insomnia), Vatarakta (Gout), Shoola (Pain) and many more. Panchavidha Kashaya Kalpana (five basic preparation) are primary potent preparations of Ayurved pharmaceutics from which several additional preparations are developed as per need of time like Vati (Pills), Avaleha (Lincus), Ghana (Solidified aqueous extract), Kshara (Alkali) and many more. An effort has been undertaken in the current study to prepare Kokilaksha Ghana from Kokilaksha Kwatha. There has been not any research work found on Kokilaksha Ghana. Aim: The aim of present study is to standardize the Kokilaksha Ghana pharmaceutically and assaying the preliminary analytical parameters. Materials and Methods: Three batches of Kokilaksha Ghana were prepared. Observation and finding of pharmaceutical study along with its preliminary assay were systematically recorded. Organoleptic properties as well as physicochemical parameters such as pH, specific gravity, total solid content, water soluble and alcohol soluble extractives, loss on drying, total ash, acid insoluble ash, and total solid content were examined in the raw material, in-process material and final product. Qualitative Phytochemical Parameters of raw material and finished product were carried out. Results: Average yield of Kokilaksha Ghana was 14.1% in contexts to dried material. The average 8.88% Loss On Drying, 12.96% Total Ash, 0.91% Acid Insoluble Ash, 43.60% Water Soluble Extractive, 10.26 Alcohol Soluble Extractive and pH of 5.89. In qualitative phytochemical parameters alkaloids, glycoside, tannin, steroid, saponin and carbohydrate were found. Conclusion: The adopted procedure, pharmaceutical outcomes and data obtained from the preliminary analysis of the present study may be considered as standard for future researches.
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References
Nikam Dattatrya, Mundada Shreekant, Mishra Dayashankar Kokilaksha: A potential Ayurvedic herb. Int. J. Res. Ayur. Pharm. 2012; 3(6):780–782
Acharya Sushruta, Sushruta Samhita, Uttartantra With commentary Ayurvedtatvasandipika by Dr. Ambikadatta Shashtri, Reprint, Chaukhambha Sanskrit Sansthan, Varanasi, 2017. 42/115
Harit, Harita Samhita, Text with “Nirmala” Hindi commentary edited by Jaiminy Pandey, 1st Edition, 2011 3–15/6
Shrimad Vriddha Vagbhatta, Astanga Sangraha, Chikitsasthana with Sashilekha vyakhya of Indu and Ayurveda Rasayana of Hemadri, edited by Hari Sadashiva Shashtri Paradakara, Chaukhambha Krishnadas Academy, Varanasi, 2016 22/18
Anonymous, Sahastrayoga, Sanskrit-Hindi-English anuvada, transaleted by Dr. D.B. Panditarao, edited by Vd. Mahendrapalsingh arya, Vandamanya Anusandhan Ekaka, CCRAS, New Delhi. 1/117
Shri Vallabha Acharya, Vaidya Chintamani, edited by Dr. K. Rama Chandra Reddy Reprint, Chaukhambha Prakashana, Varanasi,2010 23/30
Mishra Siddhinandan, Bhaishajya Kalpana Vigyan, ch.2, Bhaishajya Kalpana ke Aadharbhoot Siddhant, Reprint ed. Varanasi Chaukhamba Surbharti Parkashan 2008. p.27.
Anonymous, Guidelines on Good field collection practices for Indian Medicinal Plant, National Medicinal Plant Board department of Ayush, Ministry of Health and family welfare Govt. of India. Appendix IV P. no. 27.
Sharangdhara, Sharangdhara Samhita, Madhyamkhanda Ch. 8/1 with Jivanprada commentary, edited by Dr. smt. Shailaja Srivastava, Reprint Edition, Chaukhamnha Orientalia, Varanasi, 2015
Sharangadhara, Sharangadhara Samhita, Madyama Khanda, editor: Pandit Parasuram Shastri, Vidyasagar, Chaukhamba Orientalia, Varanasi, 6th ed. 2005, 2/1, p. 144.
Anonymous, The Ayurvedic Pharmacopoeia of India, part-I, Volume-II, First Edition, 2008, GOI, Ministry of health and family welfare, Dept. of AYUSH, New Delhi, P.160
Anonymous, The Ayurvedic Pharmacopoeia of India, part-I, Volume-II, First Edition, 2008, GOI, Ministry of health and family welfare, Dept. of AYUSH, New Delhi, P.161
Anonymous, The Ayurvedic Pharmacopoeia of India, part-I, Volume-II, First Edition, 2008, GOI, Ministry of health and family welfare, Dept. of AYUSH, New Delhi, P.213
Raman Ranjan et. al, Pharmacognostical and phytochemical study of Kokilaksha (Asteracantha longifolia), Journal of medical science and clinical research vol 5, Issue 9 p. 27511–27521
Anonymous, The Ayurvedic Pharmacopoeia of India, part-I, Volume-II, First Edition, 2008, GOI, Ministry of health and family welfare, Dept. of AYUSH, New Delhi, P.212
Anonymous, The Ayurvedic Pharmacopoeia of India, part-I, Volume-II, First Edition, 2008, GOI, Ministry of health and family welfare, Dept. of AYUSH, New Delhi, P.221
Narendra Bhatt et al, A Critical Review and Significance of Ayurvedic preparation Kwatha-Herbal decoction, International Journal of Ayurvedic Medicine, Vol 11 (2), 155–164
Dr. Samir Tanna, M.D. dissertation work, Standardization of Mamajjaka Ghana prepared by two different methods (Kwatha and Aqueous extract) w.s.r. to its antihyperglyacemic effect-IPGT & RA Gujarat 2010
Properties of Carbohydrates Glycoscience: Chemistry and Chemical Biology I–III, 2001 ISBN : 978-3 540-67764-2 Robert J. Linhardt, Hélène G. Bazin https://www.sciencedirect.com/topics/
earth-and-planetary-sciences/carbohydrate
Apeksha D. Patil, Dhiraj B. Patil, Sagar V. Ital. Comparative Pharmaceutico-Analytical Study of Kushthaghna Mahakashaya and its Ghanavati w.s.r. to evaluate its shelf life. J Ayurveda Integr Med Sci 2017;4:80–85. http://dx.doi.org/10.21760/jaims.v2i4.9331
Silpa M et.al, A PHYTOCHEMICAL STUDY ON EUPATORIUM GLANDULOSUM. Asian Journal of Pharmaceutical and Clinical Research, vol. 13/1, Jan 2020, p. 77–80, doi:10.22159/ajpcr.2020.v13i1.29534
https://atlas-scientific.com/blog/does-temperature-affect-ph/
DOI: https://doi.org/10.37591/rrjohs.v12i3.3812
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