Study the Effect of Antioxidant and Antidiabetic Property of the Selective Indian Herbal Plant Extract (A. indicum) on Type II Diabetes Mellitus

Abstract

Abutilon indicum (A. indicum) is a traditional Indian phytomedicine plant used for the treatment of several diseases such as diabetes mellitus, cardiac diseases and anti-inflammatory diseases. The aim of the study was to evaluate whether A. indicum improves insulin sensitivity and determine its active role in bioactive secondary metabolites. Aldose reductase is an enzyme which contains lower affinity towards glucose and helps in converting glucose to sorbitol and slightly catalyzed. Therefore, polyol pathway has been used to catalyze the reduction of glucose to sorbitol. In diabetes mellitus, glucose is in increased form as the insulin insensitive tissues will be causing damage to nerve tissue, retina, pupil, lens, optic nerve, iris, etc. This will reduce to glucose and leads to the formation of sorbitol through polyol pathway. As the uptake of glucose by intestinal α-glucosidase, starch will be hydrolyzed by pancreatic α-amylase. This lead to sudden change as a rise in blood glucose levels (hyperglycemia) as type 2 diabetes mellitus (T2DM). Various studies on plant extract have been performed to confirm the antioxidant assay, antimicrobial activity, and antilipidemic activity. A review study on the plant is provided to understand its medicinal properties.

Keywords: Abutilon indicum, Aldose reductase, antilipidemic activity, antidiabetic activity, antioxidant assay

Cite this Article

Lavanya L., Vadamalai Veeraraghavan, Renuka Srihari. Study the Effect of Antioxidant and Antidiabetic Property of the Selective Indian Herbal Plant Extract (A. indicum) on Type II Diabetes Mellitus. Research & Reviews: A Journal of Life Sciences. 2019; 9(Issue 1 Special): 53s–63s.