Locomotion Inhibitory Activity of Lagerstroemia speciosa Hydroalcoholic Root Extract

Authors

  • Shilpa S. Borkar Assistant Professor, Department of Pharmacology, Kamla Nehru College of Pharmacy, Nagpur, Maharashtra, India
  • Jagdish R. Baheti Professor & Principal, Department of Pharmacognosy, Kamla Nehru College of Pharmacy, Nagpur, Maharashtra, India
  • Debarshi Kar Mahapatra Assistant Professor, Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India

Keywords:

anti-depressant, extract, inhibition, Lagerstroemia speciosa, locomotor, root

Abstract

Presently, it has been found from the medical databases such as PubMed, Scopus, Google Scholar, etc. that no locomotion inhibitory activity has been explored by any research group so far for the hydroalcoholic extract of Lagerstroemia speciosa (Family: Lythraceae) root. The present study involved filling the above gap by exploring the locomotion inhibitory activity (actophotometer-based) in Swiss albino rats. The investigation showed promising therapeutic perspectives (as compared to standard drug diazepam), displayed least side-effects, and demonstrated a higher margin of safety (from high LD50 value). This particular study will positively motivate the global young researchers towards the development of a beneficial formulation as well as a useful product. However, more pre-clinical studies in various models are essentially needed to practically evaluate its effects.

References

Mahapatra DK, Shivhare RS, Gupta SD. Anxiolytic activity of some 2,3-dihydrobenzo[b][1,4]oxazepine derivatives synthesized from Murrayanine-Chalcone. Asian J Res Pharm Sci. 2018; 8(1): 25–29p.

Mahapatra DK, Bharti SK. Handbook of Research on Medicinal Chemistry: Innovations and Methodologies. New Jersey: Apple Academic Press; 2017.

Chhajed SS, Upasani CD, Wadher SJ, Mahapatra DK. Medicinal Chemistry. Nashik, India: Career Publications Private Limited; 2017.

Mahapatra DK, Bharti SK. Medicinal Chemistry with Pharmaceutical Product Development. New Jersey: Apple Academic Press; 2019.

Nurcahyanti AD, Arieselia Z, Kurniawan SV, Sofyan F, Wink M. Revisiting Bungur (Lagerstroemia speciosa) from Indonesia as an antidiabetic agent, its mode of action, and phylogenetic position. Pharmacog Rev. 2018; 12(23): 40–45p.

Bishnu C. Lagerstroemia species: A review. Int J Allied Med Sci Clin Res. 2015; 3(4): 521–524p.

Kamble MA, Mahapatra DK, Dhabarde DM, Ingole AR. Pharmacognostic and pharmacological studies of Bombax ceiba thorn extract. J Pharm Pharmacog Res. 2017; 5(1): 40–54p.

Kanhed AA, Mehere AP, Pandey KR, Mahapatra DK. 4-(2-chloroacetamido) Benzoic Acid Derivatives as Local Anesthetic Agents: Design, Synthesis, and Characterization. UK J Pharm Biosci. 2016; 4(6): 35–44p.

Mahapatra DK, Shivhare RS, Dadure KM. Transforming Murrayanine-Chalcone into corresponding 3H-benzo[b][1,4]diazepine derivatives: Accessing the anti-anxiety effect by inhibition of locomotor activity. Acta Scient Pharm Sci. 2018; 2(5): 40–44p.

Mahapatra DK, Shivhare RS, Asati V. Locomotor inhibitory activity of some Murrayanine-Chalcone based 2,3-dihydrobenzo[b][1,4]thiazepine derivatives: Exploring Anxiolytic potentials. Chron Pharm Sci. 2018; 2(1): 462–468p.

Koduru RL, Babu PS, Varma IV, Kalyani GG, Nirmala P. A Review on Lagerstroemia speciosa. Int J Pharm Sci Res. 2017; 8(11): 4540–4545p.

Mahapatra DK, Bharti SK. Drug Design. New Delhi, India: Tara Publications Private Limited; 2016.

Chhajed SS, Bastikar V, Bastikar AV, Mahapatra DK. Computer Aided Drug Design. Pune, India: Everest Publishing House; 2019.

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Published

2021-04-07

Issue

Vol. 11 No. 1 (2021)

Section

Review Article

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