Open Access Open Access  Restricted Access Subscription or Fee Access

Antimicrobial Peptide (AMP): Effective Antiacne Agents with Broad Application in the Treatment of Acne

Shahid Attar, Ashwin Harishchandra Dabhade

Abstract


Antimicrobial peptides are a group of peptides that can cause a tremendous effect on the treatment of various diseases caused by bacteria, fungi, viruses, and parasites. Antimicrobial peptides are biological molecules that show their presence in mammals, plants, and microbial species. Antimicrobial peptides contain a unique sequence of amino acids that forms structural motifs, making them unique. The presence of this unique structural molecule makes them able to cause a strong effect on disease-causing organisms. This review focuses on the acne problem and its cure by antimicrobial peptides (AMPs). Acne Vulgaris is a skin disease observed in hair follicle pores that rupture cell membranes and show inflammation at the infected site. Bacterial colonization is observed in the Acne Vulgaris. In this article, we cover the antimicrobial peptide's role in killing the pathogens that cause Acne Vulgaris. The antimicrobial activity of AMPs is analyzed by Minimal Inhibitory Concentration.


Keywords


Antimicrobial peptide, acne vulgaris, LZ1 peptide, Bp-r peptide, Propionibacterium acne

Full Text:

PDF

References


Arda O, Göksügür N, Tüzün Y. Basic histological structure and functions of facial skin. Clinics in dermatology. 2014 Jan 1;32(1):3-13.

Lei J, Sun L, Huang S, Zhu C, Li P, He J, Mackey V, Coy DH, He Q. The antimicrobial peptides and their potential clinical applications. American journal of translational research. 2019;11(7):3919.

Ciumac D, Gong H, Hu X, Lu JR. Membrane targeting cationic antimicrobial peptides. Journal of colloid and interface science. 2019 Mar 1;537:163-85.

Ciumac D, Gong H, Hu X, Lu JR. Membrane targeting cationic antimicrobial peptides. Journal of colloid and interface science. 2019 Mar 1;537:163-85.

Travkova OG, Moehwald H, Brezesinski G. The interaction of antimicrobial peptides with membranes. Advances in colloid and interface science. 2017 Sep 1;247:521-32.

Wiesner J, Vilcinskas A. Antimicrobial peptides: the ancient arm of the human immune system. Virulence 1: 440–464.

Yount NY, Yeaman MR. Multidimensional signatures in antimicrobial peptides. Proceedings of the national academy of sciences. 2004 May 11;101(19):7363-8.

Woodburn KW, Jaynes J, Clemens LE. Designed antimicrobial peptides for topical treatment of antibiotic resistant acne vulgaris. Antibiotics. 2020 Jan 13;9(1):23.

Achermann Y, Goldstein EJ, Coenye T, Shirtliff ME. Propionibacterium acnes: from commensal to opportunistic biofilm-associated implant pathogen. Clinical microbiology reviews. 2014 Jul;27(3):419-40.

Gómez DM, Lone YC, Salazar LM, Trojan J. Antimicrobial peptides, novel solution for the treatment of precancerous disease acne-A review. Trends in Medicine. 2019.

Zhang Z, Mu L, Tang J, Duan Z, Wang F, Wei L, Rong M, Lai R. A small peptide with therapeutic potential for inflammatory acne vulgaris. PLoS One. 2013 Aug 28;8(8):e72923.

Zhang Z, Mu L, Tang J, Duan Z, Wang F, Wei L, Rong M, Lai R. A small peptide with therapeutic potential for inflammatory acne vulgaris. PLoS One. 2013 Aug 28;8(8):e72923.

Huan Y, Kong Q, Mou H, Yi H. Antimicrobial peptides: classification, design, application and research progress in multiple fields. Front Microbiol 11: 1–21.

Ruggles DR, Freyman RL, Oxenham AJ. Influence of musical training on understanding voiced and whispered speech in noise. PloS one. 2014 Jan 28;9(1):e86980.

Batista AS, Ana P. Types of acne and associated therapy: A review. Amr. Res. J. Pharm. 2016;2016:1-9.

Wu Y, Qiang Y, Cao K, Zhang W, Zhang G. Inhibitory effect of the antimicrobial peptide BLP-7 against Propionibacterium acnes and its anti-inflammatory effect on acne vulgaris. Toxicon. 2020 Sep 1;184:109-15.

Wu Y, Qiang Y, Cao K, Zhang W, Zhang G. Inhibitory effect of the antimicrobial peptide BLP-7 against Propionibacterium acnes and its anti-inflammatory effect on acne vulgaris. Toxicon. 2020 Sep 1;184:109-15.

Han R, Blencke HM, Cheng H, Li C. The antimicrobial effect of CEN1HC-Br against Propionibacterium acnes and its therapeutic and anti-inflammatory effects on acne vulgaris. Peptides. 2018 Jan 1;99:36-43.

McInturff JE, Wang SJ, Machleidt T, Lin TR, Oren A, Hertz CJ, Krutzik SR, Hart S, Zeh K, Anderson DH, Gallo RL. Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnes. Journal of investigative dermatology. 2005 Aug 1;125(2):256-63.




DOI: https://doi.org/10.37591/rrjols.v13i1.3601

Refbacks

  • There are currently no refbacks.