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Evaluating the Antibacterial Perspective of Cuminaldehyde, a component of Cuminum cyminum Against Some Common Human Intestinal Pathogens

Tomy Muringayil Joseph, Debarshi Kar Mahapatra

Abstract


 

The increasing failures of chemotherapeutics and antibiotic resistance exhibited by pathogenic microbial infectious agents have led to the study on Cuminum cyminum (Family: Apiaceae) for its potential antimicrobial activity against common intestinal pathogens. Cuminaldehyde is considered as the principal component and is believed to be the chief chemical constituent for exhibiting bactericidal activity. The present investigation involved exploration of antibacterial property of cuminaldehyde against some common human intestinal pathogens such as Proteus vulgaris (P. vulgaris, MTCC 1771), Acinetobacter baumannii (A. baumannii MTCC 1425), Klebsiella pneumoniae (K. pneumoniae, MTCC 3384), Salmonella typhi (S. typhi, MTCC 733), Escherichia coli (E. coli, MTCC 2961), and Staphylococcus aureus (S. aureus, MTCC 3160). A moderate-to-satisfactory bactericidal activity was expressed by cuminaldehyde against all the six strains. However, cuminaldehyde did not express comparable antibacterial activity than that of the standard drug ciprofloxacin. Although, the current exploration will motivate the researchers in chemistry and biology area in designing and exploring better antibacterial agents in the near future to overcome several challenges such as drug resistance and the emergence of new patterns of infections.

 

Keywords: Cuminaldehyde, Cuminum cyminum, drug resistance, antibacterial, pathogen

Cite this Article

Joseph TM, Mahapatra DK. Evaluating the antibacterial perspective of Cuminaldehyde, a component of Cuminum cyminum against some common human intestinal pathogens. Research & Reviews: Journal of Herbal Science. 2018; 7(2):
10–12p.



Keywords


Cuminaldehyde, Cuminum cyminum, drug resistance, anti-bacterial, pathogen, anti-microbial

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References


Mahapatra DK, Bharti SK, Asati V. Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives. Eur J Med Chem. 2015;101:496-524p.

Evans WC. Trease and Evans' Pharmacognosy. Philadelphia: Elsevier Health Sciences; 2009.

Wichtl M. Herbal drugs and phytopharmaceuticals: a handbook for practice on a scientific basis. New York: CRC Press; 2004.

Iacobellis NS, Lo Cantore P, Capasso F, Senatore F. Antibacterial activity of Cuminum cyminum L. and Carum carvi L. essential oils. J Agricultural Food Chem. 2005;53(1):57-61p.

Johri RK. Cuminum cyminum and Carum carvi: An update. Pharmacognosy Rev. 2011;5(9):63-72p.

Mohammadpour H, Moghimipour E, Rasooli I, Fakoor MH, Astaneh SA, Moosaie SS, Jalili Z. Chemical composition and antifungal activity of cuminum cyminum L. essential oil from alborz mountain against Aspergillus species. Jundishapur J Nat Pharm Prod. 2012;7(2):50-5p.

Kamble MA, Mahapatra DK, Dhabarde DM, Ingole AR. Pharmacognostic and pharmacological studies of Bombax ceiba thorn extract. J Pharm Pharm Res. 2017;5(1):40-54p.

Telrandhe R, Mahapatra DK, Kamble MA. Bombax ceiba thorn extract mediated synthesis of silver nanoparticles: Evaluation of anti – Staphylococcus aureus activity. Int J Pharm Drug Anal. 2017;5(9):376-9p.

Mahapatra DK, Shivhare RS, Bharti SK. Novel Murrayanine based Pyrazole analogs as emerging anti-fungal candidates: Design, synthesis, characterization, and in vitro evaluation. Res Pharm. 2017;1(1):1-5p.

Mahapatra DK, Shivhare RS, Joseph TM. Design and characterization of Murrayanine linked Isoxazole derivatives: Novel class of bacteriocidal agents. Int J Res Drug Pharm Sci. 2017;1(1):11-15p.


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