Marine Algal Secondary Metabolites Promising Anti-Angiogenesis Factor against Retinal Neovascularization in CAM Model

Umadevi Subramanian, Meenakshi Sundaram Kishorekumar, Sundararaman Muthuraman, Ayyasamy Pudukadu Munusamy, Rajakumar Sundaram

Abstract


Retinal angiogenesis is an angle of new blood vessels on retinal surface. This neovascularization condition within the eye contributes to visual loss. Commonest cause of this condition includes diabetes, retinopathy of prematurity, retinal vein occlusion, etc. A variety of endothelial cell growth factors have been identified as a responsible factor and previous studies report that marine metabolites are promising molecules against retinal angiogenesis. Based on the background information collected, the present study focused to insight the anti-angiogenesis effect of metabolites present in marine algae. Findings of CAM assay suggested that the extract obtained from the marine algae Dictayota dichotoma are effective against angiogenesis.
Keywords: Retinal angiogenesis, marine algae, CAM model, anti-angiogenesis

Cite this Article
Subramanian, Kishorekumar, Rajakumar Sundaram et al. Marine Algal Secondary Metabolites Promising Anti-Angiogenesis Factor against Retinal Neovascularization in CAM Model. Research & Reviews: A Journal of Life Sciences. 2018; 8(1): 19–25p.


Keywords


Retinal angiogenesis; Marine algae; CAM model; Anti-angiogenesis

Full Text:

PDF

References


Jo DH, Kim JH, Kim JH. How to overcome retinal neuropathy: The fight against angiogenesisrelated blindness. Archives of Pharmacal Research. 2010; 33: 1557p.

Folkman J. Tumor angiogenesis: therapeutic implications. The New England Journal of Medicine. 1971; 285: 1182–1186p.

Yancopoulos GD, Davis S, Gale NW, et al. Vascular-specific growth factors and blood vessel formation. Nature. 2000; 407: 242–248p.

Carmeliet P. Angiogenesis in health and disease. Nature Medicine. 2003; 9: 653–660p.

Qazi Y, Maddula S, Ambati BK. Mediators of ocular angiogenesis. Journal of Genetics. 2009; 88(4): 495–515p.

Torresa FAE, Passalacqua TG, Velásquez AM, et al. New drugs with antiprotozoal activity from marine algae: A review. Revista Brasileira de Farmacognosia. 2014; 24(3): 265–276p.

Cheung RCF, Ng TB, Wong JH. Marine Peptides: Bioactivities and Applications. Marine Drugs. 2015; 13(7): 4006–4043p.

Jaiganesh R, Kumar NSS. Marine Bacterial Sources of Bioactive Compounds Author links open overlay panel. Advances in Food and Nutrition Research. 2012; 65: 389–408p.

Dhargalkar VK. Seaweed collection procedure. In: Verlecar, X.N. (Ed.) Seaweeds – A field manual. National Institute of Oceanography, Goa. 2004.

Culioli G, Ortalo-Magne A, Daoudi M, et al. Trihydroxylated linear diterpenes from the brown alga Bifurcaria bifurcata. Phytochemistry. 2004; 65: 2063–2069p.

Ayyad SN, Makki MS, Al-kayal NS, et al. Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma. European Journal of Medicinal Chemistry. 2011; 46: 175–182p.

Chen Z, Zhang Y, Jia C, et al. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression. Oncogene. 2014; 33(37): 4548–4557p.

Al-Kadi OS, Watson D.Texture analysis of aggressive and nonaggressive lung tumor CE CT images. IEEE Transactions on Biomedical Engineering. 2008; 55: 1822–1830p.

Najafpour GD. Biochemical Engineering and Biotechnology. Elsevier Science Ltd, Amsterdam. 2007.

Reynolds AR. Potential relevance of bell-shaped and U-shaped dose-response for the therapeutic targeting of angiogenesis in cancer. Drug-Response. 2010; 8: 253–284p.

Umadevi S, Ayyasamy PM, Rajakumar S. Computational Simulation of Retinal Angiogenesis Pathway towards the Identification of Effective Therapeutic Target and Screening of Drug Leads from Marine Metabolites. Journal of Applied Bioinformatics and Computational Biology. 2017; 6: 1p.




DOI: https://doi.org/10.37591/rrjols.v8i1.162

Refbacks

  • There are currently no refbacks.