Synthesis, Characterization and Drug delivery Application of Poly (Safranine) based triblock copolymer
Abstract
Synthesis, characterization and humidity sensor application of poly(safranin) (PSaf) was carried out under inert atmosphere. The monomer to initiator ratio [M0/I0] was maintained accurately at 100. In order to improve the molecular weight and processability it was block copolymerized with bio-compatible and bio-degradable ε-caprolactone (CL) and water-soluble tetrahydrofuran (THF) separately. Thus, the derived triblock copolymer was subjected to humidity sensor application and the results are viewed in broad approach and thus critically compared. The triblock were characterized by Fourier transform infrared (FTIR) spectroscopy, Cyclic voltammetry, GPC analysis, FESEM analysis, conductivity and drug release study. The results achieved here in the present investigation were critically compared with the literature values.
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Adhikari,B., & Majumdar,S. (2004). Polymers in sensor applications. Progress in Polymer Science, 29, 699-766.
Saxena,V., &Malhotra, B.D.(2003).Prospects of conducting polymers in molecular electronics. Current Applied Physics. 3, 293- 305.
Fleischmann,C., Lievenbrück, M.,& Ritter, H. (2015).Polymer films in sensor application:a review of present uses and future possibilities. Polymers, 7, 717-746.
Anbarasan, R., Sudha, M.,& Gopalan, A. (1999). Synthesis and characterization of nano sized NiO and its surface catalytic effect on Poly(vinyl alcohol). Polymer News,24,391-396.
Tan,L., Xie,Q., & Yao,S. (2004).Electrochel.and spectroelectrochel.studies on pyridonine
hydrochloride using poly(methylene blue) modified electrode. Electroanalysis,16,592- 597.
Liu,L.J., Cai,S.J., Tan,Y., Du,J.J., Dong,H.L., &Liao,L.Q. (2009). A recoverable, metal
free catalyst for the green polymerization of ε.CL. J. Polym. Sci.Part A: Polyer
Chemistry,47, 214-222.
Zhong,Z., Ankone,M.J.K.,Dijksfra,J., Birg,J.,& Feijen,P.J.C.(2007). Calcium methoxide
Initiated ring opening polymerization of caprolactone and lactide. Polymer Bulletin,46,
- 557.
Lin,I.H.,Cheng,C.C.,Yen,Y.C.,&Chong,F.C. (2010). Synthesis and characterization of
poly(o-anisidine)/V2O5andpoly(o-anthranilicacid)/V2O5nanocomposites.Macromolecules,
, 245-252.
Chen,H.H.,Anbarasan,R.,Quo,L.S.,&Chen,P.H. (2011). Synthesis and characterization of
novel acid functional fluorescent poly(caprolactone). Journal of Material Science. 46,
-805.
Li,J.,Xie,Cheng,W.,Nickol,H.N.R.G.,&Wang,P.G. (1999). Poly(caprolactone) modified
hydroxyl cellulose films prepared by lipase catalyzed ring opening polymerization,
Macromolecules.Macromolecules, 32, 789-794.
Zhong,X.,Ji,C.,Chan,A.,Kazarian,K.L.,Rutys,S.G.,&Dehghani, A.(2011). Conducting
polymer nano tubes for controlled drug Release. Journal Material Science Materials
medicine, 22, 279-288.
Javakhishvili,I.,Binder,W.H.,Tanner,S.,&Hvilsted,S. (2010).Facile synthesis of linear
dendritic cholesteryl poly(caprolactone)-block-(l-lysine) G2 by thiolene and azide-alkyne
click reactions.1,506-514.
Chen,H.H.,Anbarasan,R.,Quo,L.S.,&Chen,P.H. (2011). A novel report on Eosin Y
function MWCNT as an initiator for ring opening of ε-caprolactone. Material Chemistry
and Physics 126, 584-590.
Meenarathi,B.,Chen,H.H.,Chen,P.H.,&Anbarasan,R. (2013).NIR dye functionalised
MWCNT as an effective initiator for the ring opening polymerization of ε-caprolactone
.Journal of Polymer Research. 20, 118-130.
Sobczak,M.,&Kolodziejski,W. (2009). Polymerization of cyclic esters initiated by
carnitine and Tin(II) octoate, Molecules, 14, 621-632.
Liow,S.S.,Nidjaja,L.K.,Lippk,V.T.,&Abad,M.(2009).Process optimization of
poly(caprolactone) synthesized by ring opening polymerization. Experiment polymer
Letters,3,159-167.
Kerman, I.,Toppare,L.,Yilmaz,F.,&Yogci,Y. (2005).Thiophene end capped ε-caprolactone
conducting copolymers and their electrochromic properties. Journal of Macromolecular
Science Part A: Pure Applied Chemistry 42, 509-520.
Wilson,B.C.,&Jones,C.W. (2004).A recoverable, metal free catalyst for the green
polymerization of ε.CL. Macromolecules,37, 709-714.
Aourishi,A.,Deyab,S.S.A.,&Shakri,H.H.(2010).The Cationic Ring opening polymerization
of THF with 12-Tungstophosphoric acid. Chin, Journal of Polymer Science, 28, 305-
Aourishi,A.,Deyab,S.S.A.,&Shakri,H.H. (2010). Cationic Ring opening polymerization
of THF with Keggin type hetero-poly compounds as solid acid catalyst. Molecules,15,
-407.
Shokrollahi, P.(2010). Supramolecular poly(tetrahydrofuran) based on a pyrimidinone
associating motif. Iranian Polymer Journal, 19, 765-774.
Ferrahi,M.I.,&Belbachir,M. (2003). Polycondensation of THF with phthalic anhydride
induced by a proton exchanged MMT clay. International Journal of Moecular Science,
, 312-325.
Akbulnt,O.,Tasighchi,I.,Kubor,S.,Horn,Y.S.,&Mayer,A.M. (2007). Synthesis and
characterization of nano sized Zn(OH)2 and Zn(OH)2/PVA nano composite.
Electrochimica Acta.,52, 1983-1989.
Liu, S., Wu,Y., Zhang,Y.,Chi,Z.,Wei,Y., &Xu,J. (2009). Synthesis and characterization
of aniline trimer. Chemistry Letters, 38085, 840-841.
Murugesan,A.,Meenarathi,B.,Kannammal,L.,&Anbarasan,R.(2014).Synthesis,
characterization and drug delivery activity of poly(anthranilicacid) based triblock
copolymer. Synthetic Metals,189,143-151.
Anbarasan,R.,Vasudevan,&T.,Gopalan, A.(1999). Conductivity hysteresis in polymer electrolytes incorporating PTHF. Polymer News,24,391-395.
Radhika,S.,Duraimurugan,K.,Baskaran,I.,&Anbarasan,R. (2009). Metal oxide assisted chemical synthesis of poly(α-naphthylamine) and characterizations. Journal of Material Science,44,542- 555.
Balster,A.E.,Komarov,U.M.,Basanov,A.G.,Zubritskaya,N.,G.,&Machaluba, N.N., (2010). Effect of the basic process parameters during polymerization of THF with perchloric acid. Fiber Chemistry, 42, 215- 219
Chen,H.H.,Kuo,L.S.,Anbarasan.R.,&Chen,P.H. (2011). A novel report on Eosin Y function MWCNT as an initiator for ring opening of ε-caprolactone. Material Chemistry and Physics, 126, 584-590.
Agathian,K., Siva, P., Meenarathi,B., Kannammal,L.,& Anbarasan,R.(2013). Luminol initiated ring opening polymerization of Caprolactone. Indian Journal of Science, 5, 237-240.
Agathian,K., &Anbarasan,R. (2013). Synthesis and Characterizations of Novel Poly(safranine-co-luminol). Discovery Science, 6, 209-213.
DOI: https://doi.org/10.37591/jomcct.v9i2.1245
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