Hydrotropes as Effective Reaction Media for the Synthesis of Chlorothiazide

Abstract

The paper describes the synthesis of Chlorothiazide. It is a thiazide diuretic (water pill). It decreases the amount of fluid in the body by increasing the amount of salt and water lost in the urine. It is also used to lower the blood pressure as antihypertensive and to decrease edema (swelling). The synthesis of Chlorothiazide was carried out using four different hydrotropes, the effect of hydrotropes on yield, rate constant and activation energy at various temperatures and concentrations were studied