Hydrotropes as Effective Reaction Media for the Synthesis of Chlorothiazide

Authors

  • Manohar V. Lokhande Department of Chemistry, Sathaye College, Vile Parle (E), Mumbai-400057, India
  • Jagannath Kadam Department of Chemistry, Bharati Vidyapeeth College of Engineering, Navi Mumbai-400614, India
  • Ajay Patil Department of Chemistry, Bhavan’s College of Arts, Science and Commerce, Andheri (W), Mumbai-400058, India
  • Vijay Gangan Department of Chemistry, Bhavan’s College of Arts, Science and Commerce, Andheri (W), Mumbai-400058, India
  • Vijay Bhawe Department of Chemistry, Bhavan’s College of Arts, Science and Commerce, Andheri (W), Mumbai-400058, India

DOI:

https://doi.org/10.37591/jomcct.v3i1-3.2032

Keywords:

Hydrotropes, xylene sulfonic acid (XSA), cumene sulfonic acid (CSA), n-Butyl benzene sulfonic acid (n-BBSA), isobutyl benzene sulfonic acid (I-BBSA), 1HNMR, IR

Abstract

The paper describes the synthesis of Chlorothiazide. It is a thiazide diuretic (water pill). It decreases the amount of fluid in the body by increasing the amount of salt and water lost in the urine. It is also used to lower the blood pressure as antihypertensive and to decrease edema (swelling). The synthesis of Chlorothiazide was carried out using four different hydrotropes, the effect of hydrotropes on yield, rate constant and activation energy at various temperatures and concentrations were studied

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Published

2019-05-04

Issue

Vol. 3 No. 1-3 (2012)

Section

Articles

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