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Synthesis and Evaluation of New Coumarin Derivatives for Inflammatory Bowel Disease Against DSS-Induced Acute Ulcerative Colitis Mice Model

Priyanka Bajpai, Om Prakash, Amresh Gupta, Chandra Bhushan Tripathi

Abstract


Objective: The discovery of the now numerous mouse models of intestinal inflammation has increased our understanding of the intestinal inflammation that occurs in inflammatory bowel disorders (IBD). This study aimed to investigate the use of a standardized animal model subjected to coumarin derivative treatment, and the action of synthesized molecule administration of dextran sodium sulphate (DSS)-induced colitis in experimental mice. Materials and Methods: We generated a variety of unique coumarin derivatives throughout this study. Substituted benzoyl chloride was used to make coumarin derivatives such substituted 2-Ethoxy-2H-chromene and substituted 1-Methoxy-isochroman. 1H-NMR was used to confirm the chemical structures of the produced substances. However, the DSS-induced colitis animal model has some merits when compared to other similar in vivo experimental models of colitis. Because of its simplicity, it is a well-liked and commonly utilized model of inflammatory bowel disease. Results: Despite its ease of use and broad applicability, the DSS model has significant flaws that must be avoided. Several risk variables may increase sensitivity to DSS-induced lesions and alter the findings, according to the current research. Conclusion: Our findings suggest that the majority of novel coumarin derivatives met the in vivo criteria for orally active drugs, indicating that they could be promising candidates for developing more potent and effective IBD drugs.

 

 


Keywords


Inflammatory Bowel Disease, Coumarin, Crohn’s Disease, Ulcerative Colitis, DSS-induced colitis.

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References


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DOI: https://doi.org/10.37591/jomcct.v13i1.3330

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