Chitosan-Glycine Cross-Linked Microspheres for Controlled Release of Isoniazid

Authors

  • K C Gupta Polymer Research Laboratory, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India
  • MNV Ravikumar Polymer Research Laboratory, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India
  • Fawzi Habeeb Jabrail Polymer Research Laboratory, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India

DOI:

https://doi.org/10.37591/jomcct.v6i3.1969

Keywords:

Polymer, microspheres, glycine, cross-linking, drugs

Abstract

Semi-interpenetrating polymer network microspheres of chitosan with glycine have been prepared for encapsulation and controlled release of isoniazid (INH) as a model drug. The method involved the exposure of microspheres to the vapor of cross-linking agent to effect the cross-linking under mild conditions. The swelling behavior, hydrolytic degradation and loading capacity of microspheres for INH have been investigated. The prepared microspheres have shown 96% drug loading capacity, which suggested that these semi-interpenetrating polymer network microspheres are suitable to controlled release of drugs in an oral sustained delivery system.

 

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Published

2019-04-26

Issue

Vol. 6 No. 3 (2015)

Section

Articles

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