Synthesis, Characterization and Antibacterial Activity of Chalcone Derivatives

Authors

  • S. D. Nimbalkar
  • M. K. Rahangdale

Abstract

Chalcone derivatives were produced by the Claisen-Schmidt condensation of aromatic aldehydes with methyl ketones. Chalone derivatives are valuable species as they belong to keto-ethylenic components. Chalcone is a one-of-a-kind template that is linked to a variety of biological processes. 2-hydroxy-2,5- dichloro acetophenon (1) were synthesized by Fries migration and condensed with aromatic aldehyde to produce the new chalcone derivatives (2a-e). The new 1-(2-hydroxy-3,5-dichlorophenyl)-aryl-prop2-ene-1-ones (2a-e) (chalcones) were characterized using FT-IR and NMR The synthesized compounds were also screened against some bacterial species i;e, S. aureus, K. pneumoniae, S. typhi, P. vulgaris, S. flexueri, E. coli & P. aeruginosa, to evaluate their activity as promising antibacterial agents. In literature review, number of chalcone- heterocycle hybrids appear which exhibit future drugs with superior activities compared to those standards Because of the existence of the reactiveunsaturated system, chalcone has moderate to high antibacterial activity. Chalcones are secondary metabolic precursors of flavonoids, however unlike flavonoids, they possess a reactive-unsaturated carbonyl group and are thus potential inducers of cytoprotective proteins. The synthesis and antibacterial activity of new chalcone compounds obtained from 2-Hydroxy-3,5-dichloro acetophenone are described in this research.

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Published

2023-10-10

Issue

Vol. 14 No. 2 (2023)

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Research Articles

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