Glutathione peroxidase (GPx) in Breast Carcinoma

Abstract

Cancer is one of the significant problem from health perspective, every year many females are diagnosed with breast cancer out of which many die because of this disease worldwide. Oxidative stress in human body is a result of imbalance between free radical production and antioxidant defense which may result in carcinogenesis. Primary defense Primary defenses rely on the direct scavenging and inactivation of the reactive oxygen species (ROS) which includes Superoxide dismutase, Catalase, Glutathione peroxidase. In this study Glutathione peroxidase was studied in breast carcinoma and normal healthy controls. For this heparanised blood samples were collected from 60 breast carcinoma and 30 normal healthy control cases. All the data presented in the result of this study was analyzed on the SPSS statistical software version 12.0 and P – values less than 0.01 were considered highly significant. There was significant increase in Glutathione peroxidase in normal healthy controls as compared to pre and post operative cases of breast carcinoma, which proves that primary defense in normal healthy controls is more powerful than pre and post operative cases which help them fight against oxidative stress.

Keywords: Breast Cancer, Glutathione peroxidase, Oxidative stress

Cite this Article

Priyanka Verma. Glutathione peroxidase (GPx) in Breast Carcinoma. Research & Reviews: A Journal of Life Sciences. 2018; 8(3): 1–5p