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Organic Solvent Tolerant (OST) Lipases, Sources and Industrial Applications

Farooq Ahmad Ahanger, Suhaib Mohd Malik, Najeeb Wani, Sanjay Sahay, Kirti Jain

Abstract


Enzymes are natural catalysts. Lipases are used widely and have property of performing reaction in aqueous as well as organic solvents. Absolutely, in the recent times, there has been continuous increase in the number of publications, regarded properties and industrial applications of lipase catalyzed reactions. Lipases form an essential part of the industries ranging from food, dairy, pharmaceuticals, agrochemical and detergents to oleo-chemicals, tea industries, cosmetics, leather and in a number of bio-remediation processes. The use of organic solvent tolerant (OST) lipases in organic media has showed various advantages: improved activity and stability, substrate solubility are higher, simple products recovery, regio-specificity and stereo-selectivity and also capability to shift the reaction equilibrium towards synthetic area. Consequently, the search for OST enzymes has been a wide area of research. A diversity of fatty-acid esters is currently being produced commercially with immobilized lipase within non-aqueous solvents. This review illustrates the organic tolerance and industrial uses of lipases. The main stress is to study the nature of OST lipases. Also, the possible industrial applications of lipase that make it the bio-catalysts of option for the current and future have been available.
Keywords: Organic solvent tolerant (OST) lipases, sources, properties, applications

Cite this Article

Ahanger FA, Malik SM, Wani N, et al. Organic Solvent Tolerant (OST) Lipases, Sources and Industrial Applications. Research & Reviews: A Journal of Life Sciences. 2019; 9(1): 32–42p.


Keywords


Key words: OST lipases, sources, properties, applications

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REFRENCES

Yang Z, Zhang KP, Huang Y, Wang Z. Both hydrolytic and transesterification activities of Penicillium expansum lipase are significantly enhanced in ionic liquid [BMIm] [PF6]. J Mol Catal B: Enzym. 2010; 63: 23–30p.

Gutarra MLE, Godoy MG, Maugeri F, Rodrigues MI, Freire DMG, Castilho LR. Production of an acidic and thermostable lipase of the mesophilic fungus Penicillium simplicissimum by solid-state fermentation. Bioresour Technol. 2009; 100: 5249–5254p.

Gandhi NN. Applications of Lipase. J Amer Oil Chem Soc. 1997; 74: 621-634p.

Masomian M, Rahman RNZRA, Sallah AB, Basri M. A new thermostable and organic solvent tolerant lipase from Aneurinibacillus thermoaerophilus strain HZ. Process Biochem. 2013; 48: 169–175p.

Hasan F, Shah AA, Hameed A. Industrial applications of microbial lipases. Enzym Microb Technol. 2006; 39: 235–251p.

Salihu A, Alam MZ, AbdulKarim MI, Salleh HM. Lipase production: An insight in the utilization of renewable agricultural residues. Resour Conser Recycl. 2012; 58: 36–44p.

Saranya P, Kumari HS, Jothieswari M, Rao BP, Sekaran G. Lipase production from a novel thermotolerant and extreme acidophile Bacillus pumilus using palm oil as the substrate and treatment of palm oil-containing wastewater. Environ Sci Pollut Res. 2014a; 21: 3907-3919p.

Ahmed EH, Raghavendra T, Madamwar D. An alkaline lipase from organic solvent tolerant Acinetobacter sp. EH28: Application for ethyl caprylate synthesis. Bioresour Technol. 2010; 101: 3628–3634p

Ozcan B, Ozyilmaz G, Cokmus C, Caliskan M. Characterization of extracellular esterase and lipase activities from five halophilic archaeal strains. J Ind Microbiol Biotechnol. 2009; 36:105–110p.

Doukyu N, Ogino H. Organic solvent-tolerant enzymes. Biochem Engin J. 2010; 48: 270-282p.

Serdakowski AL, Dordick JS. Enzyme activation for organic solvents made easy. Trends Biotechnol. 2007; 26(1): 48–54p.

Zheng L, Baumann U, Reymond JL. An efficient one-step site-directed and site508 saturation mutagenesis protocol. Nucleic acids Res. 2004; 32: 115p.

Jaeger KE, Eggert T, Eipper A, Reetz MT. Directed evolution and the creation of enantioselective biocatalysts. Appl Microbiol Biotechnol. 2001; 55: 519–530p.

Salihu A, Alam MZ, AbdulKarim MI, Salleh HM. Effect of process parameters on lipase production by Candida cylindracea in stirred tank bioreactor using renewable palm oil mill effluent based medium. J Mol Catal B: Enzym. 2011; 72: 187–192p.

Gang W, Guang C, Ming W. “Biochemical properties Mand potential applications of an organic solvent-tolerant lipase isolated from Bacillus cereus BF-3,” African Journal of Biotechnology. 2011; 10(61): 13174–13179p.

Kotogán A, Kecskeméti A, Szekeres A, Papp T, Chandrasekaran M, Kadaikunnan S, Alharbi NS, Vágvölgyi CS, Takó M. Characterization of transesterification reactions by Mucoromycotina lipases in non-aqueous media. J. Mol. Catal. B Enzym. 2016; 127, 47–55p.

Speranza P, Macedo GA. Lipase-mediated production of specific lipids with improved biological and physicochemical properties. Process Biochem. 2012; 47, 1699–1706p.

Sá AGA, de Meneses AC, de Araújo PHH, de Oliveira D. A review on enzymatic synthesis of aromatic esters used as flavor ingredients for food, cosmetics and pharmaceuticals industries. Trends Food Sci. Technol. 2017; 69, 95–105p.

Manoel EA, Ribeiro MFP, dos Santos JCS, Coelho MAZ, Simas ABC, Fernandez-Lafuente R, Freire DMG. Accurel MP 1000 as a support for the immobilization of lipase from Burkholderia cepacia: Application to the kinetic resolution of myo-inositol derivatives. Process Biochem. 2015; 50, 1557–1564p.

Ramakrishnan V, Goveas L C, Narayan B, Halami PM. “Comparison of lipase production by Enterococcus faecium MTCC, 5695 and Pediococcus acidilactici MTCC, 11361 using fish waste as substrate: optimization of culture conditions by response surface methodology,” ISRN Biotechnology. 2013; Article ID 980562: 9p.

Vakhlu J, Kour A. “Yeast lipases: enzyme purification, biochemical properties and gene cloning,” Electronic Journal of Biotechnology. 2006; 9(1): 69–81p.

Souissi N, Bougatef A, Triki-ellouz Y, Nasri M. “Production of lipase and biomass by Staphylococcus simulans grown on sardinella (Sardinella aurita) hydrolysates and peptone,” African Journal of Biotechnology. 2009; 8(3): 451–457p.

Treichel H, de Oliveira D, Mazutti MA, Di Luccio M, Oliveira JV. “A review on microbial lipases production,” Food and Bioprocess Technology. 2010; 3(2): 182–196p.

Ertuˇgrul S, Donmez G, Takac S. “Isolation of lipase producing Bacillus sp. fromolive mill wastewater and improving its enzyme activity,” Journal of Hazardous Materials. 2007; 149(3): 720–724p.

Sumanjelin B, Rao CSVR, Babu, RS. “Isolation, characterization of lipase producing bacteria from crude rice bran oil and optimization studies by response surface methodology (RSM),” Journal of Chemical, Biological and Physical Sciences. 2013; 3: 289–296p.

Norin M, Haeffner F, Hult K, Edholm O. “Molecular dynamics simulations of an enzyme surrounded by vacuum, water, or a hydrophobic solvent,” Biophysical Journal. 1994; 67(2): 548–559p.

Fitzpatrick PA, Steinmetz ACU, Ringe D, Klibanov AM. “Enzyme crystal structure in a neat organic solvent,” Proceedings of the National Academy of Sciences of the UnitedStates of America. 1993; 90(18): 8653–8657p.

Anthonsen HW, Baptista A, Drablos F. “Lipases and esterases: a review of their sequences, structure and evolution,” Biotechnology Annual Review. 1995; 1: 315–371p.

Sarda L, Desnuelle P. “Inhibition of lipases by proteins: a kinetic study with dicarpinmonolayers,” Biochimica et Biophysica Acta. 1958; 30: 513–521p.

Bose A, Keharia H. “Production, characterization and applications of organic solvent-tolerant lipase by Pseudomonas aeruginosa AAU2,” Biocatalysis and Agricultural Biotechnology. 2013; 2: 255–266p.

Shield JW, Ferguson HD, Bommarius AS, Hatton T A. “Enzymes in reversed micelles as catalysts for organicphase synthesis reactions,” Industrial and EngineeringChemistry Fundamentals. 1986; 25(4): 603–612p.

Kumar A, Kanwar SS. “Synthesis of isopropyl ferulate using silica-immobilized lipase in an organic medium,” Enzyme Research. 201; Article ID 718949: 8p.

Speranza P, Macedo GA. “Biochemical characterization of highly organic solvent-tolerant cutinase from Fusarium oxysporum,” Biocatalysis and Agricultural Biotechnology. 2013; 2(4): 372–376p.

Wangikar PP, Rich JO, Clark DS, Dordick J S. “Probing enzymic transition state hydrophobicities,” Biochemistry. 1995; 34(38): 12302–12310p.

Ito Y, Fujii H, Imanishi Y. “Modification of lipase with various synthetic polymers and their catalytic activities in organic solvent,” Biotechnology Progress. 1994; 10(4): 398-402p.

Inada Y, Furukawa M, Sasaki H. “Biomedical and biotechnological applications of PEG- and PM-modified proteins,” Trends in Biotechnology. 1995; 13(3): 86–91p.

Kumar A, Kanwar SS. “Lipase production in solid-state fermentation (SSF): recent developments and biotechnological applications,” Dynamic Biochemistry, Process Biotechnology and Molecular Biology. 2012; 6: 13–27p.

Gu QM, Sih CJ. “Improving the enantioselectivity of C. cylindracea lipase by chemical modification,” Biocatalysis. 1992; 6: 115–126p.

Calvo MV, Plou FJ, Pastor E, Ballesteros A. “Effect of chemical modification of isoenzymes A and B from C. rugosa on their activity and stability,” Biotechnology Letters. 1995); 17(2): 171–176p.

Mogi KI, Nakajima M. “Selection of surfactant-modified lipases for interesterification of triglyceride and fatty acid,” Journal of the AmericanOil Chemists’ Society. 1996; 73(11): 1505–1512p.

Kamiya N, Goto M. “How is enzymatic selectivity of menthol esterification catalyzed by surfactant-coated lipase determined in organic media?” Biotechnology Progress. 1997; 13(4): 488–492p.

Cadirci BH, Yasa I. “An organic solvents tolerant and thermotolerant lipase fromPseudomonas fluorescens P21,” Journal of Molecular Catalysis B. 2010; 64(3-4): 155–161p.

Korman TP, Sahachartsiri B, Charbonneau DM, Huang GL, Beauregard M, Bowie1 JU. “Dieselzymes: development of a stable and methanol tolerant lipase for biodiesel production by directed evolution,” Biotechnology for Biofuels. 2013; 6: 70p.

Torres C, Otero C. “Influence of the organic solvents on the activity in water and the conformation of Candida rugosa lipase: description of a lipase-activating pretreatment,” Enzyme and Microbial Technology. 1996; 19(8): 594–600p.

Tsai SW, Dordick JS. “Extraordinary enantiospecificity of lipase catalysis in organic media induced by purification and catalyst engineering,” Biotechnology and Bioengineering. 1996; 52: 296–300p.

Zaks A, Klibanov A M. “Enzymatic catalysis in nonaqueous solvents,” Journal of Biological Chemistry. 1988; 263(7): 3194–3201p.

Wangikar PP, Michel PC, Clark DS, Dordick JS. “Structure and function of subtilisin BPN’ solubilized in organic solvents,” Journal of the American Chemical Society. 1997; 119 (1): 70–76p.

Gupta S, Bhattacharya A, Murthy CN. “Tune to immobilize lipases on polymer membranes: techniques, factors and prospects,” Biocatalysis and Agricultural Biotechnology. 2013; 2: 171–190p.

Patil KJ, Chopda MZ, Mahajan RT. “Lipase biodiversity,” Indian Journal of Science and Technology. 2011; 4: 971– 982p.

Theil F. “Lipase-supported synthesis of biologically active compounds,” Chemical Reviews. 1995; 95(6): 2203–2227p.

Ray A. “Application of lipase in industry,” Asian Journal of Pharmacy and Technology. 2012; 2: 33–37p.

Fleming HP. “Mixed cultures in vegetable fermentations,” in Mixed Cultures in Biotechnology. J. G. Zeikus and E.A. Johnson, McGrawHill, New York, NY, USA. 1991; 69–103p.

Xu H, Li M, He B. “Immobilizationof Candida cylindracea lipase on methyl acrylate-divinyl benzene copolymer and its derivatives,” Enzyme andMicrobial Technology. 1995; 17(3): 194–199p.

Abraham S, Kamini NR, Gowthaman MK. “Process strategies for alkaline lipase production using Aspergillus Niger MTCC, 2594,” Journal of Applied Pharmacy. 2011; 1: 34–115p.

Klibanov AM. “Asymmetric transformations catalyzed by enzymes in organic solvents,” Accounts of Chemical Research. 1990; 23(4): 114–120p.

Hutt AJ, Caldwell J. “The importance of stereochemistry in the clinical pharmacokinetics of the 2-arylpropionic acid non-steroidal anti-inflammatory drugs,” Clinical Pharmacokinetics. 1984; 9(4): 371-373p.

Van Dyck SMO, Lemi`ere GLF, Jonckers THM, Dommisse R, Pieters L, Buss V. “Kinetic resolution of a dihydrobenzofuran-type neolignan by lipase-catalysed acetylation,” Tetrahedron Asymmetry. 2001; 12(5): 785–789p.

Tambekar DH, Mundekar SP, Bombode VB. “Partial characterization and optimization of lipase production from Bacillus cereus isolated from haloalkaliphilic lonar lake,” International Journal of Life Sciences Biotechnology and Pharma Research. 2013; 2: 249–257p.

Jeon JH, Kim JT, Kim YJ. “Cloning and characterization of a new cold-active lipase from a deep-sea sediment metagenome,” Applied Microbiology and Biotechnology. 2009; 81(5): 865–874p.

Quax WJ, “Bacterial enzymes,” in The Prokaryotic Symbiotic Associations, Biotechnology, Applied Microbiology, M. Dworkin and S. Falkow. Springer, New York, NY, USA. 2006; 777–796p.

Rahman RNZRA, Salleh AB, Basri M. (. “Lipases: introduction,” in New Lipases and Proteases, Nova Science, New York, NY, USA. 2006; 1–22p.

Rathi P, Saxena RK, Gupta R. “A novel alkaline lipase from Burkholderia cepacia for detergent formulation,” Process Biochemistry. 2001; 37(2): 187–192p.

Rajesh B, Bhaskar Reddy I. “Lipase from organic solvent tolerant Bacillus strain C5: isolation and identification,” International Journal of Scientific Research. 2013; 2: 26–28p.

Rowe. “Biotechnology in the textile/clothing industry: a review,” Journal of Consumer Studies and Home Economics. 2001; 23: 53–61p.

Stinson SC. “Fine and intermediate chemicalsmakers emphasize new products and processes,” Chemical and Engineering News. 1995; 73(29): 10–26p.

Nagar M, Dwivedi SK, Shrivastava D. “Areviewonindustrial application in microbial lipases,” International Journal of Pharmaceutical and Research Sciences. 2013; 2: 631–641P.

Sharma R, Chisti Y, Banerjee UC. “Production, puri fication, characterization and applications of lipases,” Biotechnology Advances. 2001; 19(8): 627- 662p.

Matsumae H, Furui M, Shibatani T. “Lipase-catalyzed asymmetric hydrolysis of 3-phenylglycidic acid ester, the key intermediate in the synthesis of diltiazem hydrochloride,” Journal of Fermentation and Bioengineering. 1993; 75(2): 93–98p.

Gopinath SCB, Anbu P, Lakshmipriya T, Hilda A. “Strategies to characterize fungal lipases for applications in medicine and dairy industry,” BioMed Research International. Article ID 2013; 154549: 10p.

Masahiko A, Masahiro K, Takasi K, Kenji M, Ayari M. “Process for preparation of polyol fatty acid ester and glyceride mixture obtained,” European Patent, 1995; EP: 658629.

Benjamin S, Pandey A. “Isolation and characterization of three distinct forms of lipases from Candida rugosa produced in solid state fermentation,” Brazilian Archives of Biology and Technology. 2001; 44(2): 213–221p.

Metzger JO, Bornscheuer U. “Lipids as renewable resources: current state of chemical and biotechnological conversion and diversification,” Applied Microbiology and Biotechnology. 2006; 71(1): 13–22p.

Garlapati VK, Banerjee R. “Solvent-free synthesis of flavour esters through immobilized lipase mediated transesterification,” Enzyme Research. 2013; Article ID367410 : 6p.

Franssen MCR, Alessandrini L, Terraneo G. “Biocatalytic production of flavors and fragrances,” Pure and Applied Chemistry. 2005; 77(1): 273–279p.

Maugard T, Rejasse B, Legoy MD. “Synthesis of watersoluble retinol derivatives by enzymatic method,” Biotechnology Progress. 2002; 18(3): 424–428p.

Chandel C, Kumar A, Kanwar SS. “Enzymatic synthesis of butyl ferulate by silica-immobilized lipase in a non-aqueous medium,” Journal of Biomaterials and Nanobiotechnology. 2011; 2: 400–408p.

Chen Y, Xiao B, Chang J, Fu Y, Lv P, Wang X. “Synthesis of biodiesel from waste cooking oil using immobilized lipase in fixed bed reactor,” Energy Conversion and Management. 2009; 50(3): 668–673p.

Dizge N, Aydiner C, Imer DY, Bayramoglu M, Tanriseven A, Keskinler B. “Biodiesel production from sunflower, soybean, and waste cooking oils by transesterification using lipase immobilized onto a novel microporous polymer,” Bioresource Technology. 2009; 100(6): 1983–1991p.

Raita M, Champreda V, Laosiripojana N. “Biocatalytic ethanolysis of palm oil for biodiesel production using microcrystalline lipase in tert-butanol system,” Process Biochemistry. 2010; 45(6): 829–834p.

Li Q, Yan Y. “Production of biodiesel catalyzed by immobilized Pseudomonas cepacia lipase from Sapium sebiferum oil in micro-aqueous phase,” Applied Energy. 2010; 87(10)3148–3154p.

Farell RL, Hata K, Wall MB. “Solving pich problems in pulp and paper processes by the use of enzymes or fungi,” Advances in Biochemical Engineering/Biotechnology. 1997; 57: 197–212p.

Guti´errez A, Del R´ıo JC, Mart´ınez AT. “Microbial and enzymatic control of pitch in the pulp and paper industry,” AppliedMicrobiology and Biotechnology. 2009; 82(6): 1005– 1018p.

Bajpai P. “Application of enzymes in the pulp and paper industry,” Biotechnology Progress. 1999; 15(2): 147–157p.




DOI: https://doi.org/10.37591/rrjols.v9i1.1336

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