Marine Algal Secondary Metabolites Promising Anti-Angiogenesis Factor against Retinal Neovascularization in CAM Model

Authors

  • Umadevi Subramanian
  • Meenakshi Sundaram Kishorekumar
  • Sundararaman Muthuraman
  • Ayyasamy Pudukadu Munusamy
  • Rajakumar Sundaram

DOI:

https://doi.org/10.37591/rrjols.v8i1.162

Keywords:

Retinal angiogenesis, Marine algae, CAM model, Anti-angiogenesis

Abstract

Retinal angiogenesis is an angle of new blood vessels on retinal surface. This neovascularization condition within the eye contributes to visual loss. Commonest cause of this condition includes diabetes, retinopathy of prematurity, retinal vein occlusion, etc. A variety of endothelial cell growth factors have been identified as a responsible factor and previous studies report that marine metabolites are promising molecules against retinal angiogenesis. Based on the background information collected, the present study focused to insight the anti-angiogenesis effect of metabolites present in marine algae. Findings of CAM assay suggested that the extract obtained from the marine algae Dictayota dichotoma are effective against angiogenesis.
Keywords: Retinal angiogenesis, marine algae, CAM model, anti-angiogenesis

Cite this Article
Subramanian, Kishorekumar, Rajakumar Sundaram et al. Marine Algal Secondary Metabolites Promising Anti-Angiogenesis Factor against Retinal Neovascularization in CAM Model. Research & Reviews: A Journal of Life Sciences. 2018; 8(1): 19–25p.

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Published

2018-03-23

Issue

Vol. 8 No. 1 (2018)

Section

Research Article

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