Kisspeptin Modulates Reproduction in Ruminants

Abstract

Abstract
Kisspeptin, a neuropeptide encoded by the KiSS1 gene and its cognate, KiSS1R are the key regulators of reproduction in animals. Kisspeptin, also known as metastin, is a potent secretagogue of gonadotropin-releasing hormone (GnRH). It stimulates the GnRH neurons in the brain and generates pulses for GnRH thereby its secretion and release, and this in turn stimulates the release of LH and FSH. Owing to its importance in reproductive biology, the kisspeptin-KiSS1R system is presently regarded as an essential gatekeeper of reproduction in animals. Besides central nervous system, role of Kisspeptin during the process of placentation and pregnancy has been established recently. Therefore, kisspeptin-KiSS1R system potentially plays diverse roles in animal reproduction. Here, we review the role and physiological significance of kisspeptin in the reproduction of ruminants.
Keywords: Kisspeptin, KiSS1, metastin, KiSS1R, reproduction, ruminant, GnRH, LH

Cite this Article
M. Mondal, K.K. Baruah, M.K. Ghosh, M. Karunakaran, T.K. Dutta. Kisspeptin modulates reproduction in ruminants. Research & Reviews: Journal of Veterinary Science and Technology. 2016; 5(1): 7–12p