Immunohistochemical Detection of c-Myc in Lungs of Sheep with Ovine Pulmonary Adenocarcinoma

Abstract

vine pulmonary adenocarcinoma, a naturally occurring lung cancer of sheep was diagnosed in seventeen cases at slaughter houses. Lung tumor tissues and associated lymph nodes were collected for histopathological and immunohistochemical studies. Histologically, the lung sections from OPA cases revealed areas of non encapsulated proliferation of alveolar epithelial cells in papillary or acinar pattern. Polyploid ingrowths were also noticed into the bronchioles. On immunostaining of lung sections, JSRV-MA protein was detected in the neoplastic cells confirming the JSRV infection. There was a strong nuclear labelling for
c-Myc in most of the neoplastic cells indicating dysregulation of this particular oncogene in OPA.

Keywords: Sheep,OPA, histopathology, immunohistochemistry, c-Myc

Cite this Article

B.B.Manasa, V.Rama Devi, K.Satheesh et al. Immunohistochemical Detection of c-Myc in Lungs of Sheep with Ovine Pulmonary Adenocarcinoma. Research & Reviews: Journal of Veterinary Science and Technology. 2015; 4(2): 14–17p.